Treating Type 2 Diabetes in Patients Who Cannot Control Blood Sugar Levels By Diet and Exercise Alone. It May Be Used Alone or in Combination with other Antidiabetic Medicines. Glimepiride is a Sulfonylurea Antidiabetic Medicine. It Works By Causing the Pancreas to Release Insulin, Which Helps to Lower Blood Sugar.it is Sometimes Classified as Either the First Third Generation Sulfonylurea , or as Second-generation. Controlling High blood Sugar helps Prevent kidney damage, Blindness, Nerve Problems, Loss of Limbs and Sexual Function Problems. Proper Control of Diabetes may also Lessen Your Risk of A heart Attack or Stroke. Glimepiride Belongs to Class of Drugs Known as Sulfonylureas. It Lowers Blood Sugar By Causing the Release of Your Body's Natural Insulin. Glimepiride is Very Potent and Has a Longer Duration of Action.