Famotidine is A histamine H2-receptor Antagonist that Inhibits stomach Acid production. It is Commonly Used in the Treatment Of peptic Ulcer disease And gastroesophageal Reflux disease. Unlike cimetidine, the First H2antagonist, Famotidine Has No Effect On The cytochrome P450 enzyme System, and Does Not Appear To interact with other Drugs. Relief Of heartburn, Acid Indigestion, and Sour Stomach Treatment For gastric and duodenal Ulcerstreatment for Pathologic Gastrointestinal Hypersecretory Conditions such As zollinger-ellison Syndrome and multiple Endocrine Adenomastreatment. For gastroeso- Phageal Reflux (gerd)treatment For esophagitis Prevention Of nsaid Induced Peptic Ulcers. Famotidine is also Given to Dogs and Cats with Acid Reflux. famotidine Has Been Used in Combination with An H1 Antagonist to Treat and Prevent Urticaria caused By An Acute Allergic Reaction.